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Adv Pharm Bull. 2022;12(3): 466-475. doi: 10.34172/apb.2022.050

PMID: 35935038 PMCID: PMC9348539

Review Article

Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity

Mahsa Eskandari ¹ , Ali Awsat Mellati ² *

Cited by CrossRef: 4

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3- Nazeri Z, Mohammadzadeh G, Rashidi M, Azizdoost S, Cheraghzadeh M, Kheirollah A. 24-Hydroxycholesterol Moderates the Effects of Amyloid-β on Expression of HMG-CoA Reductase and ABCA1 Proteins in Mouse Astrocytes. 2023;12(1) [Crossref]

4- Zhang R, Wuerch E, Yong V, Xue M. LXR agonism for CNS diseases: promises and challenges. J Neuroinflammation. 2024;21(1) [Crossref]

5- Yuan J, Huang S, Jiao K, Yang S, Ge X, Liu W, Wang W, Shu H, Zhou X. Lipid Metabolism in Central Nervous System Diseases: Pathological Mechanisms and Therapeutic Advances. CNS Neurosci Ther. 2026;32(8) [Crossref]

6- Xu Y, Xu L, Xu C, Zhao M, Xu T, Xia L, Wu Y, Cao Y, Han Z. PSD-95 inhibitor Tat-NR2B9c (NA-1) protects the integrity of the blood-brain barrier after transient middle artery occlusion in rats by downregulating matrix metalloprotease-9 and upregulating endothelial nitric oxide synthase. Brain Research Bulletin. 2024;206:110836 [Crossref]

7- Zhang Q, Mao J, Wang M, Chen H, Wang Q, Zhang K, Yang L, Ma X, Wang C, Wu Y. Liver X receptor agonists in central nervous system disorders: From neuroprotection to clinical challenges. Neuroscience. 2025;584:148 [Crossref]

8- Li P, Liu X, Luo X, Luo Z, He G, Yang X. Activation of the liver X receptor α protects the blood-brain barrier against heatstroke-induced injury. International Journal of Hyperthermia. 2025;42(1) [Crossref]